Tim Sullivan

Junior Professor in Applied Mathematics:
Risk and Uncertainty Quantification

Visualisation and Uncertainty in Patient-Specific Whole-Heart Modelling

29 and 30 May 2017

Zuse Institute Berlin, Takustraße 7, 14195 Berlin, Germany

Heart disease is a clinical problem of the first order in Western society. Computational models and simulations that integrate physiological understanding with patient information derived from clinical data have huge potential to contribute to improving our understanding of both the progression and treatment of heart disease. Patient-specific models are currently created from prior anatomical and physiological knowledge that provide a reference framework for describing a patient's heart. This reference model is then augmented with clinical information describing, in part, an individual patient's physiology and pathology. Current models are primarily used for integrating and interpreting clinical data to identify the mechanisms underpinning pathologies, indices of cardiac function and/or treatment response. Despite providing new insights into cardiac physiology and pathology this approach fails to realise the full potential of computational models to not only analyse data but also to make predictive forecasts.

To realise the potential of patient specific modelling, simulation, and prediction and simulation requires the adoption of the mathematics of data assimilation and uncertainty quantification, which has enjoyed great success in meteorology, petroleum engineering and astronomy. This workshop aims to stimulate interdisciplinary collaborations and address this question of how to quantify and visualise uncertainty in medical image analysis and model predictions.

This workshop has been made possible by support from the King's College London — Freie Universität Berlin Funding Programme for Joint Research Workshops.

  • Date: 29 and 30 May 2017
  • Place: Zuse Institute Berlin, Takustraße 7, 14195 Berlin, Germany (Directions)
  • Organisers: Steven Niederer (King's College London) and Tim Sullivan (Free University of Berlin and Zuse Institute Berlin)

Travel and Accommodation

The workshop will take place at the Zuse Institute Berlin (ZIB), Takustraße 7, 14195 Berlin, Germany — the “J”-shaped building highlighted on this map. ZIB can be easily reached by public transport:

  • underground line U3 to U-Bahn station Dahlem-Dorf, then a 10-minute walk;
  • underground line U9 to S- and U-Bahn station Rathaus Steglitz, then bus X83 to bus stop Arnimallee, then a 5-minute walk;
  • of course, other routes are possible — see the website of BVG for routing information.

Berlin is served by two airports, Berlin-Tegel (TXL) and Berlin-Schönefeld (SXF). TXL is about 45 minutes from ZIB by public transport, and is mainly served by full-service airlines; SXF is about 1 hour 10 minutes from ZIB by public transport, and is mainly served by low-cost airlines.

A block of rooms at the reduced rate of 80/110 EUR per night (single/double occupancy) has been reserved at the Seminaris CampusHotel Berlin, less than 5 minutes' walk from the workshop venue. Please contact the organisers for the booking code to use when making your reservation with the hotel.

Confirmed Participants

  • Daniel Baum (ZIB)
  • Ton Coolen (KCL)
  • Jana de Wiljes (U Potsdam)
  • Marco Favino (U Svizzera Italiana & U Lausanne)
  • Steven Gilmour (KCL)
  • Leonid Gouberits (Charité)
  • Hans-Christian Hege (ZIB)
  • Titus Kühne (DHZB)
  • Rashed Karim (KCL)
  • Pablo Lamata (KCL)
  • Giovanni Montana (KCL)
  • Steven Niederer (KCL)
  • Gernot Plank (U Med Graz)
  • Christof Schütte (FUB & ZIB)
  • Julia Schnabel (KCL)
  • Alexander Sikorski (FUB & ZIB)
  • Tim Sullivan (FUB & ZIB)
  • Martin Weiser (ZIB)
  • Steven Williams (KCL)
  • James Winter (KCL)
  • Stefan Zachow (ZIB)


Schedule in PDF format

The workshop will commence at 12:50 on Monday 29 May and end at 15:00 on Tuesday 30 May. All talks will take place in the Lecture Hall of the Zuse Institute Berlin, Takustraße 7, 14195 Berlin (the “J”-shaped building highlighted on this map). Dinner on Monday evening will be held at the Alter Krug, Königin-Luise-Straße 52, 14195 Berlin, which is just off the map, immediately west of the intersection of Königin-Luise-Straße and Fabeckstraße.

Click the Information icon next to a speaker to show or hide the abstract and other supplementary information.

Monday, 12:50: Christof Schütte (President of ZIB) and Steven Niederer and Tim Sullivan (Organisers) “Welcome and Opening Remarks”
Monday, 13:00: Titus Kühne (DHZB) “The Value of Uncertainty in Clinical Studies: Two Clinical Examples” Information
Monday, 13:30: Steven Williams (KCL) “Clinical Measurements for Electrophysiology: Golden Standard or Problem Data?”
Monday, 14:00: James Winter (KCL) “Noise, error and uncertainty in cardiac research measurements”
Monday, 15:00: Julia Schnabel (KCL) “Harnessing uncertainty in medical image registration and segmentation” Information
Monday, 15:30: Ton Coolen (KCL) “Patient-specific statistical strategies — the evil twins of heterogeneity and overfitting”
Monday, 16:00: Marco Favino (U Svizzera Italiana & U Lausanne) “Efficient solution strategies for electromechanics in the heart” Information
Monday, 17:00: Daniel Baum (ZIB) “Demonstration of the Studio da Vinci” Information
Tuesday, 09:00: Stefan Zachow (ZIB) “Geometric modelling and automated heart segmentation”
Tuesday, 09:30: Gernot Plank (U Med Graz) “Image-based learning in predictive models of total heart function” Information
Tuesday, 10:00: Jana de Wiljes (U Potsdam) “Data assimilation: the seamless integration of data into computational models” Information
Tuesday, 11:00: Hans-Christian Hege (ZIB) “Uncertainty in medical computing”
Tuesday, 11:30: Steven Gilmour (KCL) “Optimal sampling for complex simulations” Information
Tuesday, 12:00: Martin Weiser (ZIB) “Eikonal models accelerating monodomain models for inverse problems and UQ” Information
Tuesday, 13:30: Pablo Lamata (KCL) “Cardiac morphology biomarkers: providing clinical value” Information
Tuesday, 14:00: Alexander Sikorski (FUB & ZIB) “An information theoretic approach to non-parametric empirical Bayes methods” Information
Tuesday, 14:30: Rashed Karim (KCL) “Seeing is believing: Flat maps of the heart and other visualisation strategies” Information